Region: The East Pacific
Well, that has sort of happened already/could happen with another "new" Deadpool movie. Harry Osborn could be a whole other situation. However, a big reason why I chose to pick Osborn as the villain is because the second half of the movie has a different, very roughly thought out plot right now, but revolves around DP being double-crossed and seeking vengeance.
The only other villain I can think of who may be able to fill in Osborn's role would have to be Fisk.